Key result
Exercise at high altitude in healthy trained subjects minimally evoked microvolt T-wave alternans compared to sea level (23 vs 22 microV, P=0.2), indicating low risk for dangerous arrhythmias.
Why the study?
Does exercise at high altitude increase the risk of malignant ventricular arrhythmias as measured by MTWA in healthy trained subjects?
Observational (n=8)
No
Does exercise at high altitude increase the risk of malignant ventricular arrhythmias as measured by MTWA in healthy trained subjects?
Absolute Event Rate: 23% vs 22%
p-value: p=0.2
Healthy trained subjects appear to be at low risk for dangerous ventricular arrhythmias during exercise at high altitude, as indicated by negative MTWA testing despite enhanced sympathetic activity.
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Low arrhythmic risk suggested for healthy trained subjects exercising at altitude; leaves open questions for patients with cardiovascular disease.
Gibelli et al. (2008) conducted an observational in Healthy subjects (n=8). Exercise at high altitude (hypoxia) vs. Exercise at sea level (normoxia) was evaluated on Microvolt T-wave alternans (MTWA) during exercise (p=0.2). Exercise at high altitude in healthy trained subjects minimally evoked microvolt T-wave alternans compared to sea level (23 vs 22 microV, P=0.2), indicating low risk for dangerous arrhythmias.
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