Why the study?
Does intracoronary nitroglycerin prevent reflex constriction of significant coronary stenosis and ischemic left ventricular dysfunction during isometric exercise?
Population
11 patients with at least one significant coronary stenosis each, undergoing cardiac catheterization
Comparison
Handgrip sustained for 4.5 min at 25% of maximum… vs Handgrip alone
Design
Other
Follow-up
Acute (during cardiac catheterization)
Authors
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Supports vasoconstriction as dominant mechanism in exercise ischemia; hypothesis-generating, should not yet change practice.
Does intracoronary nitroglycerin prevent reflex constriction of significant coronary stenosis and ischemic left ventricular dysfunction during isometric exercise?
Coronary vasoconstriction, rather than increased pressure-rate product, is the dominant mechanism for ischemic left ventricular dysfunction during isometric exercise in patients with significant coronary stenoses, and this can be reversed by intracoronary nitroglycerin.
Brown et al. (1984) studied this question.