Key result
The high-risk interactive genotype among HABP2 rs7923349, ITGA2 rs1991013, IL1A rs1609682, and NOS2A rs8081248 was independently associated with a higher risk of carotid vulnerable plaque (OR 2.86).
Cross-Sectional (n=2,377)
Yes
A specific combination of genetic variants in HABP2, ITGA2, IL1A, and NOS2A is synergistically associated with an increased risk of vulnerable carotid plaques in a Chinese population at high risk for stroke.
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May inform genetic risk stratification for carotid plaque; hypothesis-generating and requires prospective validation before clinical use.
Aim: To examine the association between carotid plaque and variants in genes involved in inflammation and endothelial function.
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Yi et al. (2020) conducted a cross-sectional in Carotid plaque (n=2,377). High-risk interactive genotype (HABP2 rs7923349, ITGA2 rs1991013, IL1A rs1609682, NOS2A rs8081248) vs. Low-risk interactive genotype (noncarriers) was evaluated on Carotid vulnerable plaque (OR 2.86, 95% CI 1.32-7.13, p=0.003). The high-risk interactive genotype among HABP2 rs7923349, ITGA2 rs1991013, IL1A rs1609682, and NOS2A rs8081248 was independently associated with a higher risk of carotid vulnerable plaque (OR 2.86).
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