⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 11, 2019Science Immunology

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T reg cells by inhibition of CDK8/19

Masahiko Akamatsu Norihisa Mikami Naganari Ohkura Ryoji Kawakami Yohko Kitagawa Atsushi Sugimoto Keiji Hirota Naoto Nakamura Satoru Ujihara T. Kurosaki Hisao Hamaguchi Hironori Harada Guliang Xia Yoshiaki Morita Ichiro Aramori Shuh Narumiya Shimon Sakaguchi

View at Publisher

Ask AI

Bookmark

Share

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Abstract

CDK8/19 inhibitors can convert naïve and memory/effector T cells into T reg cells capable of treating immunological diseases.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Akamatsu et al. (2019) studied this question.

synapsesocial.com/papers/6a1c6a6f107ed6dc7cc3c98c https://doi.org/10.1126/sciimmunol.aaw2707

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Regulatory T cells and Foxp3Original Research · 2011 · 837 citations
2Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>2003 · 4,678 citations
3Induced CD4<sup>+</sup>Foxp3<sup>+</sup>Regulatory T Cells in Immune ToleranceReview · 2012 · 595 citations
4tTregs, pTregs, and iTregs: similarities and differencesOriginal Research · 2014 · 607 citations
5Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsOriginal Research · 2003 · 1,233 citations
6Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsOriginal Research · 2004 · 802 citations
7All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacitiesOriginal Research · 2013 · 30 citations
8Reciprocal T <sub>H</sub> 17 and Regulatory T Cell Differentiation Mediated by Retinoic AcidOriginal Research · 2007 · 1,981 citations
9Collateral damage…or is love really blind?Science Immunology · 2026
10Myeloid cells run amok in injured brainsScience Immunology · 2026

More from Science Immunology

More from Kyoto University

More from The University of Osaka

More from Astellas Pharma (Japan)

More from Astellas Pharma (United States)