Why the study?
The study investigated associations between cardiovascular risk factors in childhood and fatal and non-fatal cardiovascular events in adulthood.
Are childhood cardiovascular risk factors associated with an increased risk of fatal and non-fatal cardiovascular events in adulthood?
Cohort (n=42,324)
Yes
Are childhood cardiovascular risk factors associated with an increased risk of fatal and non-fatal cardiovascular events in adulthood?
Childhood cardiovascular risk factors are independently associated with adult cardiovascular events, emphasizing the importance of early risk factor screening and management.
Supports childhood CVRF monitoring; leaves open whether early intervention reduces adult events.
Brief summary: This prospective cohort study leveraged data from the International Childhood Cardiovascular Cohorts (i3C) Consortium, including 42 324 participants at baseline and followed-up over a mean of 35 years, in order to investigate associations between cardiovascular risk factors (CVRF, including body-mass index, systolic blood pressure, total cholesterol levels, triglycerides, and smoking) in childhood (mean age 11.8 years) with fatal and non-fatal cardiovascular events in adulthood (mean age 47 years). They showed that increases in each individual CVRF in childhood, and a combined-CVRF risk score, were associated with higher risks of fatal and non-fatal cardiovascular disease events in adults, robust to adjustment for adult CVRF levels.
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DR et al. (2022) conducted a cohort in Cardiovascular events (n=42,324). Childhood cardiovascular risk factors was evaluated on Fatal and non-fatal cardiovascular events in adulthood.
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