Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.

This is the authors' abstract. We don't add key points for this paper.

Cells obtained from normal human skin synthesize predominantly type I collogen in culture. Cells obtained from the skin of an infant with a severe form of osteogenesis imperfecta were found to synthesize as much type III as type I collagen. Decreased synthesis of type I collagen could explain the tissue fragility observed in this case.