Key result
Atherogenic index of plasma, triglycerides, and BMI were positively correlated with cerebrospinal fluid pressure in IIH patients (80.36% overweight, 16.07% obese).
Why the study?
Idiopathic intracranial hypertension lacks practical objective parameters for follow-up and treatment other than optical coherence tomography, prompting investigation into the relationship between atherogenic index of plasma and cerebrospinal fluid pressure.
Is there a relationship between atherogenic index of plasma and cerebrospinal fluid pressure in patients with idiopathic intracranial hypertension?
Observational (n=56)
Is there a relationship between atherogenic index of plasma and cerebrospinal fluid pressure in patients with idiopathic intracranial hypertension?
In patients with idiopathic intracranial hypertension, cerebrospinal fluid pressure is positively correlated with BMI, triglycerides, and atherogenic index of plasma, and negatively correlated with folic acid levels.
AIP, triglycerides, and BMI correlate with CSF pressure in IIH; leaves open causal links and need for prospective metabolic intervention trials.
Background: Idiopathic intracranial hypertension (IIH) is a disease thought to be associated with obesity and rapid weight gain. There is no objective parameter with practical use in its follow-up and treatment other than optical coherence tomography. Objective: The aim of our study is to investigate the relationship between atherogenic index of plasma (AIP) and cerebrospinal fluid (CSF) pressure. Methods: Serum vitamin B12, vitamin D, homocysteine, folic acid, triglyceride (TG), high density lipoprotein cholesterol (HDL-C) levels, CSF pressure, CSF microprotein levels were recorded from the file data of patients diagnosed with IIH. AIP was calculated by dividing the TG level logarithmically by HDL-C. Height (kg) and weight (kg) data of the patients were used to calculate the body mass index (BMI). Results: File data of 64 patients were examined. 8 patients with secondary intracranial hypertension were excluded from the study. 80.36% of the patients were overweight, 16.07% were obese, 3.57% were with normal weight. There was no significant correlation between vitamin B12, vitamin D, homocysteine, HDL-C and CSF microprotein levels and CSF pressure level in patients with a diagnosis of IIH. There was a negative correlation between folic acid level and CSF pressure level, and a positive correlation between BMI, TG, AIP and CSF pressure level. Conclusion: Using folic acid supplements and drugs that reduce TG levels can contribute positively to the course of the disease.
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Şimşek et al. (2022) conducted an observational in Idiopathic intracranial hypertension (IIH) (n=56). Atherogenic index of plasma (AIP) was evaluated on Correlation between atherogenic index of plasma and cerebrospinal fluid pressure. Atherogenic index of plasma, triglycerides, and BMI were positively correlated with cerebrospinal fluid pressure in IIH patients (80.36% overweight, 16.07% obese).
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