Key result
Preemptive kilohertz frequency alternating current axonal modulation therapy significantly reduced sympathetic stimulation-evoked increases in heart rate from 22.9% to 8.7% in a porcine model.
Why the study?
Autonomic imbalance and excess sympathetic activity contribute to cardiovascular disease, and neuromodulation may offer on-demand, reversible control of cardiac sympathetic projections.
Does axonal modulation therapy using KHFAC reduce sympathetic stimulation-evoked cardiac changes and norepinephrine release in a porcine model?
Does axonal modulation therapy using KHFAC reduce sympathetic stimulation-evoked cardiac changes and norepinephrine release in a porcine model?
Axonal modulation therapy using KHFAC provides scalable, reversible, and on-demand block of sympathetic efferent outflow to the heart, reducing myocardial norepinephrine release and evoked hemodynamic changes.
Hypothesis-generating for reversible sympathetic block; leaves open clinical translation from porcine model.
Autonomic imbalance and excess sympathetic activity have been implicated in the pathogenesis of cardiovascular disease and are targets for existing medical therapy. Neuromodulation may allow for control of sympathetic projections to the heart in an on-demand and reversible manner. This study provides proof-of-concept evidence that axonal modulation therapy (AMT) blocks sympathoexcitation by defining scalability, sustainability, and memory properties of AMT. Moreover, AMT directly reduces release of myocardial norepinephrine, a mediator of arrhythmias and heart failure.
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Hadaya et al. (2021) studied Sympathoexcitation (n=14). Kilohertz frequency alternating current (KHFAC) axonal modulation therapy vs. Right sympathetic chain stimulation (RSS) without KHFAC was evaluated on Sympathetic stimulation-evoked changes in heart rate (Cohen's d 1.9, p=0.046). Preemptive kilohertz frequency alternating current axonal modulation therapy significantly reduced sympathetic stimulation-evoked increases in heart rate from 22.9% to 8.7% in a porcine model.
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