Key result
A reconstruction method using a current-arrow map based on magnetocardiogram data provided a similar action-potential waveform to a monophasic action potential without requiring a catheter.
Why the study?
Does an action potential reconstruction method using CAM based on MCG data provide a similar waveform to invasive MAP in a patient with long-QT syndrome?
Does an action potential reconstruction method using CAM based on MCG data provide a similar waveform to invasive MAP in a patient with long-QT syndrome?
A non-invasive method using magnetocardiogram signals can reconstruct action-potential waveforms similar to invasive monophasic action potentials, potentially avoiding the need for catheterization.
May enable noninvasive repolarization assessment in long-QT syndrome; hypothesis-generating and requires validation before clinical use.
A method for reconstructing an action potential during the repolarization period was developed. This method uses a current distribution-plotted as a current-arrow map (CAM)--calculated using magnetocardiogram (MCG) signals. The current arrows are summarized during the QRS complex period and subtracted during the ST-T wave period in order to reconstruct the action-potential waveform. To ensure the similarity between a real action potential and the reconstructed action potential using CAM, a monophasic action potential (MAP) and an MCG of the same patient with type-I long-QT syndrome were measured. Although the MAP had one notch that was associated with early afterdepolarization (EAD), the reconstructed action potential had two large and small notches. The small notch timing agreed with the occurrence of the EAD in the MAP. On the other hand, the initiation time of an abnormal current distribution coincides with the appearance timing of the first large notch, and its end time coincides with that of the second small notch. These results suggest that a simple reconstruction method using a CAM based on MCG data can provide a similar action-potential waveform to a MAP waveform without having to introduce a catheter.
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Kandori et al. (2004) studied Type-I long-QT syndrome (n=1). Action potential reconstruction using current-arrow map (CAM) from magnetocardiogram (MCG) vs. Monophasic action potential (MAP) measured via catheter was evaluated on Similarity between reconstructed action potential and real action potential (MAP). A reconstruction method using a current-arrow map based on magnetocardiogram data provided a similar action-potential waveform to a monophasic action potential without requiring a catheter.
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