May 1, 2026Open Access

Resting-State fMRI-based Perfusion-Timing Analysis in Cerebral Small Vessel Disease: Biomarker Potential and Mechanistic Implications

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Abstract

• Novel rs-fMRI method maps venous perfusion using endogenous blood signals. • Venous perfusion delay identified as early hallmark of CSVD pathophysiology. • Distinct perfusion phenotypes discriminate CSVD subtypes and pathophysiology. • Non-invasive biomarker potential for early neurovascular dysfunction detection.

Resting-State fMRI-based Perfusion-Timing Analysis in Cerebral Small Vessel Disease: Biomarker Potential and Mechanistic Implications

Key Points

Abstract

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