Population
Mutant and wild-type rat type 1a angiotensin II receptors transiently expressed in COS-7 cells
Comparison
Alanine replacement mutations in the NPLFY… vs Wild-type rat type 1a angiotensin II receptors
Design
Preclinical
Authors
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Challenges predicted NPXXY endocytosis role in AT1a receptors; hypothesis-generating for motif contributions to binding and activation.
The NPLFY sequence in the type 1a angiotensin II receptor is critical for agonist binding and signal transduction but does not serve as an internalization signal.
Hunyady et al. (1995) studied this question.
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