Key result
A computational simulation of AF-induced electrophysiological remodeling demonstrated a shortened repolarization period (from 325 ms to 145 ms) and effective refractory period.
Why the study?
What are the effects of electrophysiological remodeling on myocardial behavior in a computational model of the human right atrium?
What are the effects of electrophysiological remodeling on myocardial behavior in a computational model of the human right atrium?
Computational modeling demonstrates that AF-induced electrophysiological remodeling shortens the effective refractory period and attenuates the ERP-rate relationship, providing a substrate for AF recurrence.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications; leaves open whether remodeling findings extend to human AF beyond models.
Atrial fibrillation (AF) induces variations in channel characteristics of human atrial myocytes. Data from experimental AF studies was incorporated in a computational model It was used to investigate the effects of electrophysiological remodeling on myocardial behavior This model was integrated in a schematic 2D model of human right atrium including the sinoatrial node, crista terminalis, pectinate muscles, and the atrial working myocardium. Heterogeneous, anisotropic conduction was reconstructed with the monodomain approach. In both normal and pathological case, the models were excited with 68 bpm by the sinoatrial node depolarizing spontaneously. A slightly decreased conduction velocity was reconstructed in the remodeling case. The repolarization period was abbreviated from physiologically 325 ms to 145 ms. A shortened effective refractory period (ERP) and an attenuated ERP-rate relationship were identified. Both factors provide a substrate for AF recurrence
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Seemann et al. (2005) studied Atrial fibrillation. Electrophysiological remodeling simulation vs. Normal physiological simulation was evaluated on Repolarization period. A computational simulation of AF-induced electrophysiological remodeling demonstrated a shortened repolarization period (from 325 ms to 145 ms) and effective refractory period.
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