Key result
Patients with chronic atrial fibrillation exhibited significantly shortened monophasic action potential duration 90% and prolonged intra-atrial conduction time compared to patients with paroxysmal atrial fibrillation.
Observational (n=51)
Yes
Chronic atrial fibrillation is associated with more pronounced electrical remodeling (shortened MAPD90, prolonged IACT and PSRTc) compared to paroxysmal AF, but regional heterogeneity of refractoriness does not appear to increase with AF chronicity.
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Chronic AF associated with greater electrical remodeling than paroxysmal; leaves open progression mechanisms and therapeutic implications.
Background:Atrial fibrillation (AF) causes electrical remodeling of the atrium that plays an important role in increasing atrial vulnerability and the perpetuation of AF. The regional variation and heterogeneities of AFinduced electrical remodeling in patients with AF remain unclear. The purpose of present study was to test the hypothesis that regional heterogeneity of the atrial electrical properties including sinus node dysfunction is more apparent in patients with chronic AF than in patients with paroxysmal AF. Methods:The study group consisted of chronic AF (CAF, n=19), paroxysmal AF (PAF, n=19) and control group (CON, n=13). Monophasic action potential duration 90% (MAPD90) and atrial effective refractory period (AERP) were measured at 9 different sites in the right atrium using MAP catheter. Dispersion of MAPD90 and AERP were calculated from the difference between the maximum and minimum value at 9 sites, respectively. Intra-atrial conduction time (IACT) was calculated from the distance between the earliest activation and the latest one of the electrograms by 20-pole steerable catheter with 2-mm interelectrode distance which was positioned along the tricuspid annulus anterior to the crista terminalis. To evaluate sinus node function, post shock sinus node recovery time (PSRT) was measured. A rate corrected PSRT (PSRTc) was calculated from the difference between PSRT and basic sinus cycle length. Results:MAPD90 significantly shortened in patients with CAF (227.0±32.6 ms) compared with PAF (246.8±38.3 ms, p<0.05) and CON (239.1±39.3 ms, p<0.05), but AERP was not significantly different among 3 groups. The regional changes and dispersion of MAPD90 and AERP in patients with CAF did not differ from those of PAF and CON. IACT was prolonged in CAF group (73.8±22.5 ms) compared with PAF (58.2±8.0 ms, p<0.05) and CON groups (51.6±12.3 ms, p<0.05). IACT in CAF group (73.8±22.5 ms) was significantly prolonged compared with CON groups (51.6±12.3 ms, p<0.05) and was longer than that of PAF groups (58.2±8.0 ms) without statistical significance. PSRTc was longer in CAF group (758.3±525.8 ms) than in PAF group (209.5±125.0 ms, p<0.05). Conclusion: Electrical changes defined as shortened MAPD 90, prolonged IACT and PSRTc were more apparent in 논문접수일:1999년 11월 22일 심사완료일:2000년 2월 17일 교신저자:김영훈, 136-705 서울 성북구 안암동 5가 126-1 고려대학교 의과대학 내과학교실 전화:(02) 920-5445·전송:(02) 927-1478 E-mail:yhkmd@unitel.co.kr
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Hwang et al. (2000) conducted an observational in Atrial Fibrillation (n=51). Chronic Atrial Fibrillation (CAF) vs. Paroxysmal Atrial Fibrillation (PAF) and Control (CON) was evaluated on Monophasic action potential duration 90% (MAPD90) (p=<0.05). Patients with chronic atrial fibrillation exhibited significantly shortened monophasic action potential duration 90% and prolonged intra-atrial conduction time compared to patients with paroxysmal atrial fibrillation.
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