Key result
Application of strict clinical criteria revealed that only 4% to 31% of patients diagnosed with hypertensive nephrosclerosis on HCFA forms actually met the phenotype definitions.
Why the study?
Does the clinical diagnosis of hypertensive nephrosclerosis on HCFA 2728 forms accurately reflect stringent clinical phenotyping criteria in ESRD patients?
Population
607 patients with end-stage renal disease enrolled in a study to identify hypertensive nephrosclerosis…
Comparison
Application of stringent clinical phenotyping… vs Clinical diagnosis of hypertensive…
Design
Cross-sectional
Authors
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Strict phenotyping may reduce misclassification on forms; leaves open validity of prior genetic and epidemiologic studies in ESRD.
Observational (n=607)
Does the clinical diagnosis of hypertensive nephrosclerosis on HCFA 2728 forms accurately reflect stringent clinical phenotyping criteria in ESRD patients?
The clinical diagnosis of hypertensive nephrosclerosis in ESRD patients is vastly over-reported compared to stringent clinical phenotyping criteria, which may confound genetic studies and misdiagnose treatable renal diseases.
Zarif et al. (2000) conducted an observational in Hypertensive nephrosclerosis / End-stage renal disease (n=607). Clinical phenotyping criteria (Schlessinger and AASK) vs. HCFA 2728 form diagnosis was evaluated on Proportion of patients satisfying clinical phenotyping criteria for hypertensive nephrosclerosis. Application of strict clinical criteria revealed that only 4% to 31% of patients diagnosed with hypertensive nephrosclerosis on HCFA forms actually met the phenotype definitions.
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