Key result
A lumped parameter numerical model demonstrated that isolated right ventricular dysfunction significantly alters both pulmonary and systemic hemodynamics, with severe systolic dysfunction reducing right ventricular ejection fraction from 55% to 15%.
Why the study?
Studies dedicated to a detailed description of the hemodynamic role of the right ventricle and the effect of isolated RV dysfunction on the whole circulation were lacking.
Does simulated isolated right ventricular dysfunction alter global cardiovascular hemodynamics in a lumped parameter model?
Does simulated isolated right ventricular dysfunction alter global cardiovascular hemodynamics in a lumped parameter model?
This numerical study demonstrates that isolated right ventricular dysfunction significantly impacts both pulmonary and systemic hemodynamics, highlighting the critical role of the right ventricle in global cardiovascular function.
The role played by the right ventricular (RV) dysfunction has long been underestimated in clinical practice. Recent findings are progressively confirming that when the RV efficiency deteriorates both the right and the left circulation is (significantly) affected, but studies dedicated to a detailed description of RV hemodynamic role still lack. In response to such a gap in knowledge, this work proposes a numerical model that for the first time evaluates the effect of isolated RV dysfunction on the whole circulation. Lumped parameter modelling was applied to represent the physio-pathological hemodynamics. Different grades of impairment were simulated for three dysfunctions i.e., systolic, diastolic, and combined systolic and diastolic. Hemodynamic alterations (i.e., of blood pressure, flow, global hemodynamic parameters), arising from the dysfunctions, are calculated and analysed. Results well accord with clinical observations, showing that RV dysfunction significantly affects both the pulmonary and systemic hemodynamics. Successful validation against in vivo data proved the clinical potentiality of the model i.e., the capability of identifying the degree of RV impairment for given hemodynamic conditions. This study aims at contributing to the improvement of RV dysfunction recognition and treatment, and to the development of tools for the clinical management of pathologies involving the right heart.
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Comunale et al. (2020) studied Right ventricular dysfunction. Numerical simulation of right ventricular dysfunction (systolic, diastolic, and combined) vs. Healthy simulated condition was evaluated on Hemodynamic alterations (blood pressure, flow, global hemodynamic parameters). A lumped parameter numerical model demonstrated that isolated right ventricular dysfunction significantly alters both pulmonary and systemic hemodynamics, with severe systolic dysfunction reducing right ventricular ejection fraction from 55% to 15%.
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