What does this research mean for the field?

The translational efficiency of mRNA containing stable 5' secondary structures changes dramatically during Xenopus development, being highly repressed during early oogenesis and after the midblastula transition but fully potentiated in newly fertilized eggs. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 15, 1991Science

Translational Potentiation of Messenger RNA with Secondary Structure in Xenopus

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Structured PICO

Population

Xenopus oocytes, eggs, and early embryos

Intervention

Injection of mRNA with a stable hairpin secondary structure in the 5' noncoding region (hpCAT)

Comparator

Injection of mRNA without a stable hairpin secondary structure (CAT)

Outcome

Translational efficiencysurrogate

Translational efficiency of mRNA with stable secondary structure varies dramatically during Xenopus oogenesis and early development.

Discussion

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Implication

Translational control of structured mRNA is highly stage-specific in Xenopus; leaves open relevance to mammalian oocytes and clinical translation.

Cite This Study

Fu et al. (1991) studied this question.

synapsesocial.com/papers/6a1ca68e6552df3dce1d803a https://doi.org/10.1126/science.1990443

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Implication

Translational control of structured mRNA is highly stage-specific in Xenopus; leaves open relevance to mammalian oocytes and clinical translation.

Translational Potentiation of Messenger RNA with Secondary Structure in Xenopus

Structured PICO

Discussion

Implication

Cite This Study

Translational Potentiation of Messenger RNA with Secondary Structure in Xenopus

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider