Why the study?
Does chronic ethanol ingestion alter myocardial function and lipid metabolism in a canine model?
Population
Mongrel dogs
Comparison
Ethanol fed as 36% of calories for up to 22 months vs Control group maintaining body weight…
Design
Preclinical
Follow-up
up to 22 months
Authors
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Hypothesis-generating for ethanol-induced diastolic stiffness under stress; leaves open translation to human alcoholic cardiomyopathy.
Does chronic ethanol ingestion alter myocardial function and lipid metabolism in a canine model?
Chronic ethanol ingestion in a canine model induces diastolic stiffness and lipid metabolism abnormalities without malnutrition, analogous to preclinical alcoholic cardiomyopathy.
Regan et al. (1974) studied this question.
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