Fundamental strategies and search methods for the development of a synthesis plan for heterocyclic compounds are presented.These methods have been incorporated into the synthesis design system WODCA (Workbench for the Organization of Data for Chemical Applications).The use of this computer system is illustrated with several target compounds containing heterocycles of various degrees of complexity such as lysergic acid, 3-benzylpiperidie, and rotenone.
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Gasteiger et al. (1995) studied this question.