Why the study?
Human endogenous retroviruses have been implicated in the pathogenesis of nervous system disorders, and their involvement might offer new treatment strategies.
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Design
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Inhibition of human endogenous retroviruses may offer new therapeutic strategies for incurable nervous system disorders like multiple sclerosis and ALS.
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.
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Gröger et al. (2021) studied this question.
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