What does this research mean for the field?

Natriuretic peptides (including ANP and BNP) and cGMP lack sufficient sensitivity and specificity to be used as routine screening tools for completely asymptomatic left ventricular dysfunction. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

August 1, 1996HeartOpen Access

Natriuretic peptides and cyclic guanosine 3',5'-monophosphate in asymptomatic and symptomatic left ventricular dysfunction.

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Why the study?

Are natriuretic peptides and cGMP accurate markers for screening asymptomatic left ventricular dysfunction?

Population

107 subjects, including 37 patients with asymptomatic left ventricular dysfunction, 32 patients with mild to…

Comparison

Measurement of CT-ANP, NT-ANP, beta-ANP, BNP… vs Controls and symptomatic heart failure patients

Design

Cross-sectional

Authors

WFW FriedlGladstone Institutes JMJohannes MairInnsbruck Medical University STS. N. ThomasThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Natriuretic peptides have limited screening utility for asymptomatic LV dysfunction; challenges prior marker suggestions but leaves role open.

Structured PICO

Are natriuretic peptides and cGMP accurate markers for screening asymptomatic left ventricular dysfunction?

Population

107 subjects, including 37 patients with asymptomatic left ventricular dysfunction, 32 patients with mild to moderate congestive heart failure, and 38 controls.

Intervention

Measurement of CT-ANP, NT-ANP, beta-ANP, BNP, and cGMP at rest and 3 minutes after exercise

Comparator

Controls and symptomatic heart failure patients

Outcome

Diagnostic sensitivity and specificity for detecting asymptomatic left ventricular dysfunctionsurrogate

Natriuretic peptides and cGMP have limited sensitivity and specificity and are unlikely to be suitable for routine screening of completely asymptomatic left ventricular dysfunction.

Cite This Study

Friedl et al. (1996) studied this question.

synapsesocial.com/papers/6a1cbd0d784db799e7899653 https://doi.org/10.1136/hrt.76.2.129

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Implication

Natriuretic peptides have limited screening utility for asymptomatic LV dysfunction; challenges prior marker suggestions but leaves role open.

Natriuretic peptides and cyclic guanosine 3',5'-monophosphate in asymptomatic and symptomatic left ventricular dysfunction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Natriuretic peptides and cyclic guanosine 3',5'-monophosphate in asymptomatic and symptomatic left ventricular dysfunction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider