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Targeted drug delivery using metal-organic frameworks (MOFs) has become an area of significant interest due to their unique ability to change their configuration and porosity. MOFs offer a tuneable porous hybridization that enhances drug interactions and allows for greater loadings. The drugs are enclosed within nanoparticles designed to protect them against enzymatic and chemical degradation, ensuring targeted delivery to specific locations with precise dosages. This technology has demonstrated immense potential to revolutionize drug delivery. However, as the number of nanomaterial varieties and uses continues to grow, there is a pressing need to investigate their potential toxicity and release kinetics. Cytotoxicity, a pilot project test, has emerged as a crucial diagnostic for toxicity evaluation of medical equipment. Investigations are underway to describe the effects of nanoparticles with minimal exposure and to address possible toxicity after release. Despite the potential benefits of MOFs in targeted drug delivery, their toxicity and release kinetics remain poorly understood. Researchers are currently exploring different strategies to optimize the performance of MOFs in targeted drug delivery while minimizing their potential adverse effects. Recent advances in targeted drug delivery using MOFs have shown great promise, but their potential toxicity must be thoroughly evaluated before they can be safely used in clinical applications.
Gautam et al. (Fri,) studied this question.