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January 29, 2019Blood AdvancesOpen Access

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models

Trisha R. Sippel Stefan Radtke Tayla M. Olsen Hans‐Peter Kiem Anthony Rongvaux

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Abstract

Key Points Next-generation humanized mice differentially support human HSPC maintenance and myelopoiesis. MISTRG mice support long-term human HSPC maintenance demonstrated by quaternary transplantation and development of human tissue macrophages.

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Cite This Study

Sippel et al. (2019) studied this question.

synapsesocial.com/papers/6a1cf07c784db799e789b4de https://doi.org/10.1182/bloodadvances.2018023887

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