Biomarkers S100B and Neuron-Specific Enolase Predict Outcome in Hypothermia-Treated Encephalopathic Newborns*

An N. Massaro; Taeun Chang; Stephen Baumgart; Robert McCarter; Karin B. Nelson; Penny Glass

doi:10.1097/pcc.0000000000000155

April 28, 2014Pediatric Critical Care MedicineOpen Access

Biomarkers S100B and Neuron-Specific Enolase Predict Outcome in Hypothermia-Treated Encephalopathic Newborns*

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Key Points

The study aims to evaluate serum S100B protein and neuron-specific enolase as predictors of neurodevelopmental outcomes in hypothermia-treated encephalopathic newborns.
Prospective longitudinal cohort study design
Measure serum S100B and neuron-specific enolase at 0, 12, 24, and 72 hours during hypothermia
Evaluate neurodevelopmental outcomes using the Bayley Scales of Infant Development-II at 15 months.
15 of 83 infants (18%) died during the newborn period
Higher serum levels of S100B (OR 2.5, 95% CI 1.3-4.8) and neuron-specific enolase (OR 2.1, 95% CI 1.2-3.6) were linked to poorer cognitive outcomes
Similar associations were found for motor outcomes with S100B (OR 2.6, 95% CI 1.2-5.6) and neuron-specific enolase (OR 2.1, 95% CI 1.2-3.6).

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Implication

Prospective cohort study reveals biomarkers predicting neurodevelopmental outcomes in newborns with encephalopathy, suggesting potential clinical applications.

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Cite This Study

Massaro et al. (2014) studied this question.

synapsesocial.com/papers/6a1d104128423f2ce504bf77 https://doi.org/10.1097/pcc.0000000000000155

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Biomarkers S100B and Neuron-Specific Enolase Predict Outcome in Hypothermia-Treated Encephalopathic Newborns*

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Biomarkers S100B and Neuron-Specific Enolase Predict Outcome in Hypothermia-Treated Encephalopathic Newborns*

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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