Composite Lymphoma of the Orbit Treated With Rituximab

In Brief We describe an unusual case of composite lymphoma (CL) in the orbit. The clinical history and biopsy specimen of an 82-year-old woman with a right orbital mass were evaluated. The orbital biopsy contained a dense lymphocytic infiltration and nodules of large lymphocyte that immunostained positive for CD20. Flow cytometric immunophenotyping showed two distinct populations of cells, confirming the diagnosis of a simultaneous follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient was treated with CD20 antibody (rituximab) and is in remission at 3 months follow-up. An 82-year-old woman developed an orbital mass that was diagnosed as a composite lymphoma of the orbit with immunohistochemical staining and flow cytometry, and showed complete remission after treatment with rituximab.