The Diagnostic Value of Predictive Factors for Clinically Insignificant Prostate Cancer

Purpose: In the present study, we identified the pre-operative predictive factors of insignificant prostate cancer and we analyzed their diagnostic accuracy. Material and Methods: Of a total 343 patients who had undergone radical prostatectomy, 33 patients (9.6%) were diagnosed with insignificant cancer that was characterized by a total cancer volume ≤0.5cc, a Gleason score (GS)≤6, a T stage≤2c and no positive surgical margin. We found the statistically significant factors after comparing of preoperative clinico-pathological findings between two groups and determined the diagnostic accuracy of the identified predictors. Results: Of several factors, prostate-specific antigen (PSA) level (p=0.04, odds ratio (OR)=4.3 3.589≤95%confidence interval (CI)≤5.692), PSA den-sity (PSAD) (p=0.01, OR=6.6, 2.115≤95%CI≤278.826), biopsy GS (p=0.03, OR=4.6, 1.114≤95%CI≤12.568) and volume of the largest cancer (p=0.02, OR=5.6, 2.471≤95%CI≤9.725) were analyzed as independent predictors