Why the study?
What are the optimal anesthetic management and perioperative surveillance strategies to prevent myocardial ischemia in high-risk patients?
What are the optimal anesthetic management and perioperative surveillance strategies to prevent myocardial ischemia in high-risk patients?
Perioperative management of high-risk patients should focus on avoiding myocardial ischemia through hemodynamic control, appropriate monitoring, and pharmacological therapies like alpha-2 agonists and beta-blockers.
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May inform perioperative agent selection in high-risk patients; leaves open confirmatory RCTs before practice change.
The intraoperative management of the high-risk patient has received a great deal of attention and research during the past decade. Based on the available evidence, there appears to be no one best anesthetic technique or agent. More importantly, the goals of intraoperative management are to avoid myocardial ischemia, which include preventing tachycardia, and maintaining normothermia and adequate hematocrit. Perioperative monitoring includes transesophageal echocardiography, pulmonary artery catheter and ST segment monitoring. Perioperative pharmacological treatment with alpha-2 agonists and beta-adrenergic blocking agents are associated with a reduced incidence of perioperative myocardial ischemia and improved long-term survival, respectively. Future research will be required to determine whether prophylactic therapy or early treatment of perioperative myocardial ischemia will lead to improved outcome.
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Lee A. Fleisher (1998) studied this question.
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