A group contribution method has been developed that uses the LC50 values (measured for fathead minnow) for 130 diverse organic compounds. The 130 selected compounds were constituted from 16 chemical groups with —log(LC50) values ranging from 0.85 to 6.09. The method was then used to predict the LC50 values for 10 additional compounds, not in the training set, with good agreement between the predicted and measured values.
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Gao et al. (1992) studied this question.
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