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June 1, 2026Frontiers in ToxicologyOpen Access

Advancing chemical mixture toxicity assessment using advanced in vitro NAMs: current status and future perspectives

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Authors

HKHyunwoo KimDKDonghyeon KimJCJinhee Choi

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Overview

Review evaluates advanced in vitro NAMs for assessing chemical mixture toxicity, suggesting regulatory implications.

Key Points

  • This review aims to evaluate the application of advanced in vitro NAMs in chemical mixture toxicity assessments and their regulatory potential.
  • Literature search on PubMed for studies from 2021-2025, identifying 353 in vitro NAM studies related to chemical mixture toxicity.
  • 70 advanced in vitro NAM-based studies were analyzed for methodologies and applications.
  • Categorization of advanced models included route-of-exposure-relevant models, Omics, 3D models, stem cell-based models, and HTS/HCI approaches.
  • Advanced in vitro NAMs were applied to diverse mixtures such as air pollutants, PFAS, and phthalates.
  • They helped compare mixture effects versus individual chemicals and identify toxicity drivers within mixtures.
  • Future value depends on technological developments and integration into specific testing strategies for regulatory contexts.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a1d208702fbce9130636e51https://doi.org/10.3389/ftox.2026.1757928
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