This review provides a comprehensive overview of the history, methodology, and clinical perspectives of endothelial function assessment, highlighting its role in predicting cardiovascular events while emphasizing the need for standardized diagnostic criteria.
Endothelial function testing may refine CV risk assessment; leaves open standardized criteria before clinical adoption.
In 1986, endothelial function was measured for the first time in patients with atherosclerotic coronary arteries. Since then, several methods for assessment of endothelial function, such as endothelium-dependent vasodilation induced by intra-arterial infusion of vasoactive agents using coronary angiography, Doppler flow guide wire, mercury-filled Silastic strain-gauge plethysmography, flow-mediated vasodilation, reactive hyperemia-peripheral arterial tonometry, and vascular response using an oscillometric method have been performed in humans. This review focuses on the assessment of endothelial function, including measurement history, methodological issues, and clinical perspectives.
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Yukihito Higashi (2015) studied this question.
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