What question did this study set out to answer?

The research aims to explore how age-related sleep changes can be influenced by diet restriction and Prdm13 signaling in the DMH.

June 1, 2026Life Science Alliance0 citationsOpen Access

Correction: Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH and diet restriction in mice

STShogo TsujiNational Center for Geriatrics and Gerontology CBCynthia S. BraceWashington University in St. Louis RYRuiqing YaoNational Center for Geriatrics and Gerontology

Key Points

The research aims to explore how age-related sleep changes can be influenced by diet restriction and Prdm13 signaling in the DMH.
Investigated sleep-wake patterns in mice across different ages
Examined the effects of diet restriction
Analyzed the role of Prdm13 signaling in DMH neurons
Age-associated sleep changes were reduced by diet restriction
Prdm13 signaling in DMH neurons appears to play a beneficial role in sleep patterns
Suggests potential interventions targeting Prdm13+ DMH neurons for age-related sleep issues

Abstract

This study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes.

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