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June 1, 2026Journal of the American Association for Laboratory Animal Science

Effects of Extended-Release Liposomal Bupivacaine on Postoperative Mechanical and Thermal Hypersensitivity in C57BL/6 Mice (Mus musculus)

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Authors

AWAshley I WangMDMarie P DuongJFJennifer R Frohlich

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Overview

Randomized trial evaluates the effects of liposomal bupivacaine on pain sensitivity in mice, suggesting limited efficacy for thermal hypersensitivity.

Key Points

  • This study aims to evaluate the effects of extended-release liposomal bupivacaine on postoperative mechanical and thermal hypersensitivity in C57BL/6 mice.
  • Adult female and male C57BL/6NCrl mice (N=...) were randomly assigned to receive one of three treatments: MELOX/XR-BUP, standard bupivacaine (SB), or liposomal bupivacaine (LB).
  • Mechanical hypersensitivity (MH) and thermal hypersensitivity (TH) were assessed using von Frey and Hargreaves tests on specified postoperative days.
  • Surgery was performed on day 0, and assessments continued through day 4 postoperatively.
  • The LB group showed significant reduction in MH on postoperative days 1-4 (exact values not provided).
  • The MELOX/XR-BUP group also significantly reduced MH on all postoperative days compared to baseline, with statistical details not specified.
  • The SB group exhibited significant MH attenuation, but neither SB nor LB demonstrated substantial TH reduction during the postoperative period.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a1d218f02fbce91306377cchttps://doi.org/10.30802/aalas-jaalas-26-029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Liposomal Bupivacaine: A Delay Rather Than Elimination of Rebound Pain in Mouse Postoperative Model2025
  2. 2Pharmacokinetics and Analgesic Efficacy of a Novel Extended-Release Buprenorphine Formulation in Mice2026
  3. 3Pharmacokinetic Evaluation of a Topical Extended-release Analgesic in Mice2024 · 2 citations
  4. 4Comparing analgesic efficacy of microsphere-based and liposomal bupivacaine: a dose-response and time-dependent study in the spared nerve injury rat model2026
  5. 5Evaluation of Efficacy of 2 Extended-release Bupivacaine Products in a Porcine Model of Incisional Pain2024 · 3 citations