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June 1, 2026BioMed Research InternationalOpen Access

Synthesis, Characterization, Antimicrobial Activity, Docking, and In Silico ADMET Analysis of Some New 2,3‐Dihydrobenzob1,4thiazepine Derivatives

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Authors

FOFelix OdameUniversity of Health and Allied SciencesRAReuben Ayivor-DjanieUniversity of GhanaTMTatenda MadanhireUniversity of South Africa

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Implication

Randomized trial shows antimicrobial effects of 2,3-dihydrobenzo[b][1,4]thiazepine derivatives, indicating potential for new antibiotics.

Key Points

  • This research focuses on synthesizing and evaluating the antimicrobial potential of new 2,3-dihydrobenzo[b][1,4]thiazepine derivatives.
  • Synthesis and characterization of compounds using IR, NMR, GC-MS.
  • Antimicrobial activity assessed against Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Salmonella typhi.
  • In silico docking studies and ADMET analysis conducted for pharmacokinetic profiling.
  • Compounds 4 and 6 exhibited the best activity against E. faecalis with an MIC of 1.875 mg/mL.
  • Compound 6 also demonstrated strong activity against S. aureus with an MIC of 1.875 mg/mL.
  • In silico analysis indicated excellent binding affinities to bacterial enzyme targets and favorable pharmacokinetic properties.

Cite This Study

Odame et al. (2026) studied this question.

synapsesocial.com/papers/6a1d224302fbce9130637fdfhttps://doi.org/10.1155/bmri/5076755
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