Grizaceo/protein-lab: fibromyalgia GWAS-transcriptomics reanalysis.

Q: What does this research mean for the field?

GWAS-prioritized neural genes, specifically MDGA2 and DRD2, are robustly upregulated in the peripheral blood mononuclear cells of fibromyalgia patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Cristóbal Luis Muñoz Rojas

doi:10.5281/zenodo.20466871

May 30, 2026Open Access

Grizaceo/protein-lab: fibromyalgia GWAS-transcriptomics reanalysis.

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Key Points

This research aims to reanalyze existing GWAS and transcriptomic data to identify differential expressions of neural genes in fibromyalgia.
Conducted sensitivity analysis across five models on public transcriptomic datasets.
Performed a cross-context comparison between PBMCs and whole blood for neural GWAS signals.
Reviewed evidence from a dopamine agonist randomized controlled trial.
MDGA2 and DRD2 found to be upregulated in fibromyalgia PBMCs across all five models (sex-adjusted).
Demonstrated a contrast in gene expression dependent on cell fraction; neural GWAS signals in PBMCs vs mast cell signals in whole blood.
No replication of Pramipexole RCT findings after 21 years.

Implication

Randomized trial analyzes gene expression in fibromyalgia patients, highlighting key neural gene signals.

Abstract

First stable release of the fibromyalgia GWAS-transcriptomics reanalysis. Preprint: GWAS-Prioritized Neural Genes Are Differentially Expressed in Fibromyalgia PBMCs: A Targeted Reanalysis of Public Transcriptomic Cohorts (Draft v2.0, May 2026) Key scripts: sensitivity_analysis_gse221921.py: Five-model sensitivity analysis (primary). cross_context_gwas_neural_genes.py: PBMC vs. whole blood cross-context comparison. phase2_rct_review.py: Dopamine agonist RCT evidence table. Key results: MDGA2 and DRD2 robustly upregulated in FM PBMCs (5/5 models, sex-adjusted). Cell-fraction-dependent contrast: neural GWAS signal in PBMCs, mast cell panel in whole blood. Pramipexole RCT (Holman & Myers 2005) remains unreplicated after 21 years. Datasets: GSE221921 (PBMC, n=189), GSE67311 (whole blood, n=140) GWAS source: Kerrebijn et al. 2025 (PMID 41001472)

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Cite This Study

Cristóbal Luis Muñoz Rojas (2026) studied this question.

synapsesocial.com/papers/6a1d226d02fbce913063823e https://doi.org/10.5281/zenodo.20466871

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Grizaceo/protein-lab: fibromyalgia GWAS-transcriptomics reanalysis.

Key Points

Implication

Abstract

Discussion

Cite This Study

Grizaceo/protein-lab: fibromyalgia GWAS-transcriptomics reanalysis.

Key Points

Implication

Abstract

Discussion

Cite This Study

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