A Nested Case-Control Protocol to Test Whether Probiotic Supplementation Is Associated with Reduced Delirium Tremens Risk: Rationale from a Reintegration-Failure Model of Withdrawal

This project contains a clinical research design protocol applying the MTZ (Mediated Transitional Zone) framework to Delirium Tremens. It proposes a nested case-control study testing whether probiotic supplementation is associated with reduced DT risk, mediated by gut-brain axis biomarkers. The protocol includes a pre-specified statistical analysis plan, causal mediation analysis, and nine falsifiable predictions. No original patient data are reported.