Seven incidences of clinically significant pulmonary embolus in severely granulocytopenic and thrombocytopenic patients with acute myelocytic leukemia are reported. Each patient had received multiple platelet concentrate transfusions but showed no rise in post-transfusion platelet count. The possible roles of granulocytopenia and ineffective platelet transfusion in facilitating pulmonary embolus are discussed. It is concluded that severe thrombocytopenia offers no protection against pulmonary embolus.
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Wiernik et al. (1969) studied this question.
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