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January 20, 2020Risk AnalysisOpen Access

Global Transmission of Live Polioviruses: Updated Dynamic Modeling of the Polio Endgame

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Why the study?

Nearly 20 years after the 2000 target for eradication, live polioviruses continue to circulate across all three serotypes, posing challenges for the polio endgame.

Population

Global population stratified into 72 blocks of 10 subpopulations of approximately 10.7 million people

Design

Global differential equation-based transmission and stochastic risk modeling study

Follow-up

2019-2023

Authors

DKDominika A. KalkowskaMPMark A. PallanschSWSteven G. F. Wassilak

Discussion

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Overview

Prompts urgent review of polio strategies and timelines; leaves open whether intensified measures can meet eradication targets.

Structured PICO

P
Population
Global population of 7.7 billion people as of 2019, stratified into 72 blocks according to country 2019 income levels, each containing 10 subpopulations of approximately 10.7 million people.
I
Intervention
Global Polio Eradication Initiative Strategic Plan 2019-2023 (immunization and outbreak response strategies)
O
Outcome
Eradication of serotype 1 wild poliovirus and cessation of oral poliovirus vaccine serotype 2-related viruses by 2023

Updated dynamic modeling suggests the Global Polio Eradication Initiative is not on track to achieve its 2023 eradication goals for wild poliovirus 1 or OPV2-related viruses.

Cite This Study

Kalkowska et al. (2020) studied this question.

synapsesocial.com/papers/6a1d2546838abd2e0378e69fhttps://doi.org/10.1111/risa.13447
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