Why the study?
Deep analgosedation or general anesthesia is mandatory for pulsed-field ablation of AF, but the optimal sedation regimen regarding adverse events remained unclear.
Does continuous remimazolam-ketamine DAS or continuous propofol-opioid TIVA reduce sedation-related adverse events compared to intermittent propofol-opioid DAS in patients undergoing pulsed-field ablation for atrial fibrillation?
Does continuous remimazolam-ketamine DAS or continuous propofol-opioid TIVA reduce sedation-related adverse events compared to intermittent propofol-opioid DAS in patients undergoing pulsed-field ablation for atrial fibrillation?
Remimazolam-ketamine deep analgosedation is superior to propofol-opioid regimens for pulsed-field ablation of atrial fibrillation, significantly reducing the risk of procedural hypoxemia and hypotensive events.
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Sochorová et al. (2025) studied this question.
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