What question did this study set out to answer?

To develop a radioimmunoassay that can quantify various classes and subclasses of platelet-bound immunoglobulins (PBIg).

Quantification of platelet‐bound immunoglobulins of different class and subclass using radiolabeled monoclonal antibodies: assay conditions and clinical application

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Randomized trial quantifies platelet-bound immunoglobulins in thrombocytopenic patients, suggesting clinical utility for diagnosis.

To develop a radioimmunoassay that can quantify various classes and subclasses of platelet-bound immunoglobulins (PBIg).
Modified radioimmunoassay for both PBIgG and PBIgM using radiolabeled monoclonal antibodies.
Conducted analyses with gel filtration to determine binding ratios.
Evaluated sensitivity and specificity of the assay in 147 thrombocytopenic patients.
The assay showed a sensitivity of 61% and specificity of 45% for diagnosing idiopathic thrombocytopenic purpura (ITP).
PBIgG subclasses were found in 60% of ITP and 61% of secondary thrombocytopenia (STP) patients.
No correlation was found between the total amount of PBIgG or PBIgM and platelet count in either condition.

Tijhuis et al. (1991) studied this question.

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