Pharmacokinetics of Lamisil® in humans

The pharmacokinetics of terbinafine (Lamisil) have been studied in humans using both unlabelled and radiolabelled drug. Lamisil is well absorbed (> 70%) while maximal plasma concentrations of parent drug are reached within 2 hours following oral administration. Lamisil is extensively distributed to all tissues in the body with a total volume of distribution of approximately 1000 I (Vd). The half-life of elimination (β-phase) of Lamisil in man is approximately 16 hours. Lamisil is not excreted as an unchanged drug but is completely metabolized in the liver; 15 metabolites have been identified. Lamisil does not affect the metabolism of antipyrine, but its own metabolism is modified by the coadministration of either cimetidine or rifampicin.