ing" property, i.e., desoxycorticosterone, resulted in the formation of a compound with relatively low "sodium and chloride-retaining" potency, the addition of a hydroxyl group on CQ7 to a compound which initially possessed moderate "sodium and chlorideretaining" potency, i.e., corticosterone, resulted in the formation of a compound in which all "sodium and chloride-retaining" effect had disappeared.In this latter instance, the new compound actually facilitated sodium and chloride excretion (Fig. 1).
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George Kingsley Zipf (1942) studied this question.