Course and Prognosis in Amyotrophic Lateral Sclerosis

In 1849, Duchenne (de Boulogne) described "muscular atrophy with fatty transformation,"1 *and a year later Aran, using Duchenne's material, elaborated the description and named the condition progressive muscular atrophy (P.M.A.).²In 1860, Duchenne added his unsurpassed clinical depiction of "progressive muscular paralysis of the tongue, palate and lips," now known as progressive bulbar palsy.³In 1868 Charcot delivered a lecture at the Salpetriere on the association of progressive muscular atrophy