Why the study?
Does rapid heart rate, vagal stimulation, or acute myocardial ischemia affect the threshold for ventricular fibrillation in a canine model?
Population
Canine model with normal or ischemic left ventricle
Comparison
Rapid heart rate, strong vagal stimulation, and… vs Normal heart rate, fixed heart rate without…
Design
Preclinical
Authors
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Rapid heart rate may lower VF threshold in ischemia; hypothesis-generating in canine model, human translation leaves open.
Does rapid heart rate, vagal stimulation, or acute myocardial ischemia affect the threshold for ventricular fibrillation in a canine model?
Rapid heart rate lowers the ventricular fibrillation threshold, particularly during acute myocardial ischemia, suggesting a mechanistic basis for correcting tachycardia in acute myocardial infarction.
James et al. (1977) studied this question.
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