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August 28, 2019The Journal of Organic ChemistryOpen Access

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors

Ian de Toledo Thiago A. Grigolo James M. Bennett Jonathan M. Elkins Ronaldo A. Pilli

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Abstract

-imidazoles (23%-69%, three steps). This approach was also employed in the synthesis of known inhibitor GSK3037619A.

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Toledo et al. (2019) studied this question.

synapsesocial.com/papers/6a1d43407328fa9a742f3a00 https://doi.org/10.1021/acs.joc.9b01844

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