Key result
Elevated blood plasma eosinophil cationic protein (≥11 ng/mL) was associated with a significantly higher incidence of in-stent restenosis compared to lower levels (63% vs 19%, p=0.019).
Why the study?
Is elevated blood plasma eosinophil cationic protein associated with in-stent restenosis after sirolimus-eluting stent implantation?
Observational (n=32)
Is elevated blood plasma eosinophil cationic protein associated with in-stent restenosis after sirolimus-eluting stent implantation?
Absolute Event Rate: 63% vs 19%
p-value: p=0.019
Elevated eosinophil cationic protein levels are associated with a higher incidence of in-stent restenosis after sirolimus-eluting stent implantation, suggesting a role for eosinophil activation in its pathogenesis.
May support eosinophil role in restenosis after sirolimus-eluting stents; hypothesis-generating, should not yet change practice.
The aim of this study was to assess the involvement of eosinophil cationic protein, a marker of eosinophil activation, in the development of in-stent restenosis after drug-eluting stent implantation. Follow-up angiography at 6 to 12 months was performed in 32 patients who were treated with percutaneous coronary intervention and implantation of sirolimus-eluting stents. Blood plasma levels of eosinophil cationic protein (ECP) and total immunoglobulin E (IgE) were measured by enzyme-linked immunosorbent assay and the level of C-reactive protein (hs-CRP) by high-sensitivity nephelometry. According to angiography data, in-stent restenosis occurred in 13 patients, while 19 patients did not develop it. There were no differences between the hs-CRP and IgE levels in patients with or without restenosis. In contrast, ECP level was higher in patients with restenosis compared with that in patients without restenosis [17.7 ng/mL (11.2-24.0) vs. 9.0 ng/mL (6.4-12.9), p = 0.017]. The incidence of in-stent restenoses was 63% in patients with ECP level higher than or equal to 11 ng/mL, and 19% in patients with an ECP level lower than 11 ng/mL (p = 0.019). These findings suggest that elevated eosinophil activation may play an important role in the pathogenesis of in-stent restenosis after implantation of drug-eluting stents.
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Gabbasov et al. (2011) conducted an observational in In-stent restenosis after drug-eluting stent implantation (n=32). Elevated eosinophil cationic protein (ECP) level (≥11 ng/mL) vs. ECP level <11 ng/mL was evaluated on In-stent restenosis (p=0.019). Elevated blood plasma eosinophil cationic protein (≥11 ng/mL) was associated with a significantly higher incidence of in-stent restenosis compared to lower levels (63% vs 19%, p=0.019).
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