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Investigates DCAF1's role in ribosome biogenesis, impacting cell growth, indicating its importance for development.
loss increases free RPL11, resulting in L11-MDM2 association and p53 activation. Cumulatively, these results reveal a critical function for DCAF1 in ribosome biogenesis and define a molecular basis of DCAF1 function in cell proliferation and development.
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Han et al. (2020) studied this question.
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