Preparation and Physicochemical Evaluation of Topical Cream Ivermectin 1% for Treatment of Rosacea

Background: Rosacea is a prevalent disease throughout the world. Various studies have shown that the hair follicle mites Demodex has a key role in the rosacea pathogenesis. The current study aims to formulate a formulation of ivermectin 1% for rosacea treatment. Methods: The researchers sought an ivermectin topical cream in following a stable preparation for the treatment of rosacea. Investigation of the active ingredient in the formulation was conducted according to standards. The formulation was monitored as an ICH guideline within six months. Results: The resulting formula did not show any physical instability during accelerated stability studies, and the appearance of the formula did not change. During the storage period, the preparation displayed no significant changes in density, viscosity, pH, and uniformity. Additionally, no microbial contamination was occurred in this formulation. Conclusion: The study data indicated that the proper o/w cream produced from the active ingredient Ivermectin. Administration of ivermectin topical dosage form reduces the chronic use of antibiotic in the rosacea treatment. Our data can aid physicians to prescribe high potential formulation for rosacea treatment. This topical ivermectin with the standard formulation assessments showed the preparation was sufficiently stable and can use in the treatment of rosacea.