Why the study?
Does coronary stent implantation improve event-free survival compared to conventional balloon angioplasty alone in patients with stable or unstable angina?
Does coronary stent implantation improve event-free survival compared to conventional balloon angioplasty alone in patients with stable or unstable angina?
Coronary stent implantation significantly improves 12-month event-free survival compared to balloon angioplasty alone, primarily by reducing the need for repeat revascularization.
May support stents over PTCA in angina; leaves open need for RCT confirmation.
The clinical outcome after successful conventional coronary balloon angioplasty is compared with that of stent implantation after 30 days and 12 months. The study took place at the Divisions of Cardiology and Thoracic Radiology, Norrland University Hospital, Umeå, a referral centre for northern Sweden. The first 100 consecutive patients with stable or unstable angina undergoing successful percutaneous transluminal coronary angioplasty (PTCA) in 1994 and the first 100 consecutive patients undergoing successful coronary stent implantation in 1995 were included. The cardiac endpoints studied were death, myocardial infarction, need for repeat PTCA or coronary artery bypass grafting (CABG). Significantly more adverse cardiac events were observed in the PTCA group compared with the stent group. Event-free 12 months' follow-up (no deaths, myocardial infarction or re-intervention) was 64% in the PTCA group and 86% in the stent group (p < 0.005). The main explanation for the observed difference was a reduction in the need for a repeat PTCA (7 vs 18, p < 0.05) or CABG (4 vs 12, p < 0.05) in the stent group. Patients with stable or unstable angina who can be treated with a stent have a better clinical outcome than those treated with coronary balloon angioplasty only.
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Anders Eriksson Johan B. Nilsson (2000) studied this question.
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