Why the study?
Given increased cardiovascular risk in HCV infection and DAA metabolic pathways, drug-drug interactions with antiplatelets or anticoagulants are common, but clinical trials are lacking.
How should drug-drug interactions between direct-acting antiviral agents and anticoagulants or antiplatelets be managed in patients with HCV infection?
How should drug-drug interactions between direct-acting antiviral agents and anticoagulants or antiplatelets be managed in patients with HCV infection?
This position paper provides expert consensus and practical suggestions for managing drug-drug interactions between HCV direct-acting antivirals and antithrombotic therapies.
The natural history of chronic hepatitis C virus (HCV) infection has changed after the introduction of direct-acting antiviral agents (DAAs). Screening programs have been ongoing to reach the World Health Organisation's goal of HCV elimination by 2030, and most infected people are eligible for treatment. Given the increased cardiovascular risk in people with HCV infection and the metabolic pathways of DAAs, it is not uncommon to face the issue of drug-drug interactions (DDIs) with antiplatelet or anticoagulant drugs. In the absence of clinical trials, we offer suggestions to deal with DDIs in case of treatment of patients with DAAs who are also receiving antiplatelet or anticoagulant drugs, based on the best available evidence from pharmacodynamics and pharmacokinetics studies in conjunction with clinical experience in the field of haemostasis and thrombosis.
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Tombolini et al. (2024) conducted a review in Chronic hepatitis C virus (HCV) infection. Direct-acting antiviral agents (DAAs) and anticoagulants or antiplatelets was evaluated. This position paper provides expert suggestions based on pharmacodynamics and pharmacokinetics for managing drug-drug interactions between direct-acting antiviral agents and antithrombotic drugs.
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