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In mixed granulocytic asthma, the OXPHOS pathway drives the metabolic reprogramming of Th17 cells to produce LIGHT, which controls airway remodeling, and dual blockade of LIGHT and OXPHOS reverses these disease features. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

The metabolic reprogramming of T cells controls airway remodeling in severe asthma

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