Key result
COX-2 inhibitors are associated with adverse cardiovascular effects, including increased risks of myocardial infarction and heart failure exacerbation, warranting caution in patients with existing CVD.
Why the study?
Do NSAIDs increase cardiovascular risk in patients with existing cardiovascular disease?
Do NSAIDs increase cardiovascular risk in patients with existing cardiovascular disease?
Due to the risk of adverse cardiovascular events such as myocardial infarction and heart failure exacerbation, NSAIDs should be prescribed with caution in patients with existing cardiovascular disease.
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May warrant caution with COX-2 inhibitors in CVD patients; leaves open precise risk quantification versus alternatives.
Amer et al. (2010) conducted a review in Cardiovascular disease. NSAIDs (COX-1 and COX-2 inhibitors) was evaluated. COX-2 inhibitors are associated with adverse cardiovascular effects, including increased risks of myocardial infarction and heart failure exacerbation, warranting caution in patients with existing CVD.